Acta Medica 3 2012 2647.indd
نویسندگان
چکیده
the aim of our study was to determine the effect of selected cytostatics on a human ovarian cancer cell line a2780 as a model system for ovarian cancer treatment. this cell line is considered cisplatin-sensitive. Panel of tested cytostatics included cisplatin, paclitaxel, carboplatin, gemcitabine, topotecan and etoposide. these cytostatics have a different mechanism of action. to evaluate cytotoxic potential of the tested compounds, the methods measuring various toxicological endpoints were employed including morphological studies, Mtt assay, dynamic monitoring of cell proliferation with xCelligence, cell cycle analysis, caspase 3 activity and expression of proteins involved in cell cycle regulation and cell death. the a270 cell line showed different sensitivity towards the selected cytostatics, the highest cytotoxic effect was associated with paclitaxel and topotecan.
منابع مشابه
Acta Medica 3 2012 2647.indd
latitude gradients and secular trends in europe and north america have been found in the male-female ratio at birth (M/f: male births divided by total births) which is expected to be 0.515. annual national data for Czechoslovakia and the post-Czechoslovakian (Czech Republic and slovakia) countries for male and female live births were obtained from the world health organisation and analysed with...
متن کاملActa Medica 4/12 2802.indd
Unilateral otosclerosis combined with avascular necrosis of stapes crura is a rare entity. it should be considered in a case of high grade otosclerosis. Symptoms are the same as in patients who suffer from common otosclerosis. Patients complain on progressive hearing loss and tinnitus. The diagnosis is made clinically by conventional audiologic evaluation and radiologically by x-ray mastoid Sch...
متن کامل